Eye Blog

Pterygium surgery

Monday, August 01, 2011

HISTORY OF PTERYGIUM TREATMENT

PTERYGIUM has a long history of difficult treatment. THE word pterygium comes from the Greek word pterygos, which means ‘wing’.

SUSTARA (1 000 BC, Egypt) treated pterygium with pulverised salt and stimulation with a palmbranch. When the pterygium was inflamed and swollen, he tore it out with force and removed any remaining tissue with a flesh-stripping ointment. He also described the ease with which the lesion reappeared! HIPPOCRATES (469 BC) suggested the use of eye drops containing lead, zinc, copper, iron, bile juices, urine and maternal milk.
AMBROSE PARE (16th century) said, “You’ve learned that a pterygium is an illness that always recurs, even when you’ve done everything in your power to cure it.” This concept has remained true to the present day!

MANY TREATMENTS HAVE BEEN USED TO IMPROVE SURGICAL OUTCOMES:

1957 Topical radio-therapy with strontium 90 (Sr90)

1962 Use of antimitotics to prevent recurrence
1964 Use of amniotic membrane to repair the conjunctival tissue loss following excision of the pterygium
1985 Grafting autologous conjunctiva (own conjunctiva harvested from another area) over the open area

THE BASIC SURGICAL TECHNIQUES USED TODAY

Bare sclera : Stripping the pterygium and leaving the wound open to close naturally (an almost 30% recurrence)

Apposisional repair : Repairing the wound by suturing the edges together with vicryl, silk or nylon 8/0 (10-25% recurrence)
Torsional flap : Repairing the wound with a flap of adjacent healthy conjunctiva (5-10%recurrence)
Free flap : Use of autologous conjunctiva or amniotic membrane to cover the wound, sutured with 8/0 (5-10% recurrence)

Despite all efforts, surgical outcomes have remained indifferent.

UNTIL RECENTLY, OUTCOMES of pterygium surgery have been, to say the least, indifferent. The affected eye often remained red and inflamed, with visible scarring and a high rate of recurrence. But with a new technique that uses the tissue glue Tisseel, the cosmetic results have improved significantly, and the recurrence rate has dropped to less than 1% in the authors last 4 years of surgery.
Not all South African eye surgeons are currently performing the new procedure, which requires a bit of practice, but the results are so astonishing that it will soon gain ground.

The new technique still involves an autologous free conjunctival flap, usually harvested from the conjunctiva below the upper eyelid – but instead of sutures fastening the new flap over the bare area, Tisseel glue is now used.

WHAT IS TISSEEL?

It's a tissue glue that has been used extensively in general and neurosurgery. It simulates the final stage of the coagulation cascade to produce a biocompatible fibrin matrix clot that adheres to connective tissue like a natural blood clot. It contains concentrations of fibrinogen and thrombin that when mixed, duplicates clot formation with a high level of elasticity.


WHAT ARE THE ADVANTAGES OF TISSEEL OVER SUTURES?

The procedure is less time-consuming, saving almost half of the theatre time. There is also much less irritation or pain.

Inflammation is much less because the area is covered but there are no sutures that irritate the surrounding area. Less follow-up is needed (day one post-op and the 1 month later). In my hands the results are definitely far superior.

My experience with Tisseel surgery since 2007

– Where I used Tisseel I found the following:

There was no need for antimetabolites. Recurrences after previous conventional surgeries were successfully treated. The patient comfort was superior from day one. Cosmetic results were also superior.
In a retrospective questionnaire of my first 100 pterygium surgery patients done in 2007, we scored an average of 9/10 for subjective impression of success and cosmetic results.
-One of the 100 cases involved pterygium surgery performed on a bride-to-be only six weeks before her wedding. I would never have dreamt of attempting pterygium surgery using the ‘older’ techniques!!
With the low risk profile of Tisseel it is now safer to do pteryguim surgery on even the small cosmetically worrying lesions.


ABOVE LEFT: The eye a week before the procedure
. ABOVE RIGHT: One month later


ABOVE LEFT: The eye of a bride, one day before surgery and six weeks before her wedding day. ABOVE RIGHT: A week before the wedding